Association of Parkinson’s Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case–Control Study in France
Identifieur interne : 000707 ( Main/Exploration ); précédent : 000706; suivant : 000708Association of Parkinson’s Disease and Its Subtypes with Agricultural Pesticide Exposures in Men: A Case–Control Study in France
Auteurs : Frédéric Moisan [France] ; Johan Spinosi [France] ; Laurène Delabre [France] ; Véronique Gourlet [France] ; Jean-Louis Mazurie [France] ; Isabelle Bénatru [France] ; Marcel Goldberg [France] ; Marc G. Weisskopf [États-Unis] ; Ellen Imbernon [France] ; Christophe Tzourio [France] ; Alexis Elbaz [France]Source :
- Environmental Health Perspectives [ 0091-6765 ] ; 2015.
Descripteurs français
- Wicri :
- geographic : France.
English descriptors
- KwdEn :
- Adult, Aged, Case-Control Studies, Farmers (statistics & numerical data), France (epidemiology), Humans, Logistic Models, Male, Middle Aged, Occupational Exposure (statistics & numerical data), Odds Ratio, Parkinson Disease (drug therapy), Parkinson Disease (epidemiology), Pesticides (adverse effects), Vitis.
- MESH :
- chemical , adverse effects : Pesticides.
- geographic , epidemiology : France.
- drug therapy : Parkinson Disease.
- epidemiology : Parkinson Disease.
- statistics & numerical data : Farmers, Occupational Exposure.
- Adult, Aged, Case-Control Studies, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Vitis.
Abstract
Pesticides have been associated with Parkinson’s disease (PD), but there are few data on important exposure characteristics such as dose–effect relations. It is unknown whether associations depend on clinical PD subtypes.
We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes.
As part of a French population-based case–control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression.
There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models, as well as a synergistic interaction between duration and intensity (
This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation.
Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. 2015. Association of Parkinson’s disease and its subtypes with agricultural pesticide exposures in men: a case–control study in France. Environ Health Perspect 123:1123–1129;
Url:
DOI: 10.1289/ehp.1307970
PubMed: 25815770
PubMed Central: 4629732
Affiliations:
- France, États-Unis
- Aquitaine, Auvergne-Rhône-Alpes, Massachusetts, Nouvelle-Aquitaine, Poitou-Charentes, Rhône-Alpes
- Bordeaux, Lyon, Poitiers
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Le document en format XML
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type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Bénatru">Isabelle Bénatru</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Service de Neurologie, CHU Poitiers, Poitiers, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU Poitiers, Poitiers</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Université Versailles St-Quentin, UMRS 1018, Villejuif, France</addr-line></nlm:aff><country 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Saint-Maurice</wicri:regionArea><wicri:noRegion>Saint-Maurice</wicri:noRegion><wicri:noRegion>Saint-Maurice</wicri:noRegion></affiliation><affiliation wicri:level="3"><nlm:aff id="aff3"><addr-line>Unité mixte de recherche épidémiologique et de surveillance en transport, travail et environnement (Umrestte), Université Lyon, Lyon, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Unité mixte de recherche épidémiologique et de surveillance en transport, travail et environnement (Umrestte), Université Lyon, Lyon</wicri:regionArea><placeName><region type="region">Auvergne-Rhône-Alpes</region><region type="old region">Rhône-Alpes</region><settlement type="city">Lyon</settlement></placeName></affiliation></author><author><name sortKey="Delabre, Laurene" sort="Delabre, Laurene" uniqKey="Delabre L" first="Laurène" last="Delabre">Laurène Delabre</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département santé travail, Institut de veille sanitaire, Saint-Maurice</wicri:regionArea><wicri:noRegion>Saint-Maurice</wicri:noRegion><wicri:noRegion>Saint-Maurice</wicri:noRegion></affiliation></author><author><name sortKey="Gourlet, Veronique" sort="Gourlet, Veronique" uniqKey="Gourlet V" first="Véronique" last="Gourlet">Véronique Gourlet</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>INSERM, U708, Neuroepidemiology, Bordeaux/Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, Bordeaux/Paris</wicri:regionArea><wicri:noRegion>Bordeaux/Paris</wicri:noRegion><wicri:noRegion>Bordeaux/Paris</wicri:noRegion></affiliation></author><author><name sortKey="Mazurie, Jean Louis" sort="Mazurie, Jean Louis" uniqKey="Mazurie J" first="Jean-Louis" last="Mazurie">Jean-Louis Mazurie</name><affiliation wicri:level="3"><nlm:aff id="aff4"><addr-line>Caisse départementale de la Gironde, Mutualité sociale agricole, Bordeaux, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Caisse départementale de la Gironde, Mutualité sociale agricole, Bordeaux</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Aquitaine</region><settlement type="city">Bordeaux</settlement></placeName></affiliation></author><author><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Bénatru">Isabelle Bénatru</name><affiliation wicri:level="3"><nlm:aff id="aff5"><addr-line>Service de Neurologie, CHU Poitiers, Poitiers, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Service de Neurologie, CHU Poitiers, Poitiers</wicri:regionArea><placeName><region type="region">Nouvelle-Aquitaine</region><region type="old region">Poitou-Charentes</region><settlement type="city">Poitiers</settlement></placeName></affiliation></author><author><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><affiliation wicri:level="1"><nlm:aff id="aff6"><addr-line>Université Versailles St-Quentin, UMRS 1018, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Université Versailles St-Quentin, UMRS 1018, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author><author><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. Weisskopf</name><affiliation wicri:level="2"><nlm:aff id="aff7"><addr-line>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts</wicri:regionArea><placeName><region type="state">Massachusetts</region></placeName></affiliation></author><author><name sortKey="Imbernon, Ellen" sort="Imbernon, Ellen" uniqKey="Imbernon E" first="Ellen" last="Imbernon">Ellen Imbernon</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département santé travail, Institut de veille sanitaire, Saint-Maurice</wicri:regionArea><wicri:noRegion>Saint-Maurice</wicri:noRegion><wicri:noRegion>Saint-Maurice</wicri:noRegion></affiliation></author><author><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>INSERM, U708, Neuroepidemiology, Bordeaux/Paris, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM, U708, Neuroepidemiology, Bordeaux/Paris</wicri:regionArea><wicri:noRegion>Bordeaux/Paris</wicri:noRegion><wicri:noRegion>Bordeaux/Paris</wicri:noRegion></affiliation></author><author><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><affiliation wicri:level="1"><nlm:aff id="aff1"><addr-line>Département santé travail, Institut de veille sanitaire, Saint-Maurice, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>Département santé travail, Institut de veille sanitaire, Saint-Maurice</wicri:regionArea><wicri:noRegion>Saint-Maurice</wicri:noRegion><wicri:noRegion>Saint-Maurice</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="aff8"><addr-line>INSERM U1018, Centre for Research in Epidemiology and Population Health, Villejuif, France</addr-line></nlm:aff><country xml:lang="fr">France</country><wicri:regionArea>INSERM U1018, Centre for Research in Epidemiology and Population Health, Villejuif</wicri:regionArea><wicri:noRegion>Villejuif</wicri:noRegion><wicri:noRegion>Villejuif</wicri:noRegion></affiliation></author></analytic><series><title level="j">Environmental Health Perspectives</title><idno type="ISSN">0091-6765</idno><idno type="eISSN">1552-9924</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Farmers (statistics & numerical data)</term><term>France (epidemiology)</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Occupational Exposure (statistics & numerical data)</term><term>Odds Ratio</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (epidemiology)</term><term>Pesticides (adverse effects)</term><term>Vitis</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Pesticides</term></keywords><keywords scheme="MESH" type="geographic" qualifier="epidemiology" xml:lang="en"><term>France</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="statistics & numerical data" xml:lang="en"><term>Farmers</term><term>Occupational Exposure</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Case-Control Studies</term><term>Humans</term><term>Logistic Models</term><term>Male</term><term>Middle Aged</term><term>Odds Ratio</term><term>Vitis</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>France</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Pesticides have been associated with Parkinson’s disease (PD), but there are few data on important exposure characteristics such as dose–effect relations. It is unknown whether associations depend on clinical PD subtypes.</p></sec><sec><title>Objectives</title><p>We examined quantitative aspects of occupational pesticide exposure associated with PD and investigated whether associations were similar across PD subtypes.</p></sec><sec><title>Methods</title><p>As part of a French population-based case–control study including men enrolled in the health insurance plan for farmers and agricultural workers, cases with clinically confirmed PD were identified through antiparkinsonian drug claims. Two controls were matched to each case. Using a comprehensive occupational questionnaire, we computed indicators for different dimensions of exposure (duration, cumulative exposure, intensity). We used conditional logistic regression to compute odds ratios (ORs) and 95% confidence intervals (CIs) among exposed male farmers (133 cases, 298 controls). We examined the relation between pesticides and PD subtypes (tremor dominant/non-tremor dominant) using polytomous logistic regression.</p></sec><sec><title>Results</title><p>There appeared to be a stronger association with intensity than duration of pesticide exposure based on separate models, as well as a synergistic interaction between duration and intensity (<italic>p-</italic>interaction = 0.04). High-intensity exposure to insecticides was positively associated with PD among those with low-intensity exposure to fungicides and vice versa, suggesting independent effects. Pesticide exposure in farms that specialized in vineyards was associated with PD (OR = 2.56; 95% CI: 1.31, 4.98). The association with intensity of pesticide use was stronger, although not significantly (<italic>p</italic>-heterogeneity = 0.60), for tremor-dominant (<italic>p-</italic>trend < 0.01) than for non-tremor–dominant PD (<italic>p-</italic>trend = 0.24).</p></sec><sec><title>Conclusions</title><p>This study helps to better characterize different aspects of pesticide exposure associated with PD, and shows a significant association of pesticides with tremor-dominant PD in men, the most typical PD presentation.</p></sec><sec><title>Citation</title><p>Moisan F, Spinosi J, Delabre L, Gourlet V, Mazurie JL, Bénatru I, Goldberg M, Weisskopf MG, Imbernon E, Tzourio C, Elbaz A. 2015. Association of Parkinson’s disease and its subtypes with agricultural pesticide exposures in men: a case–control study in France. 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Mandel</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>France</li><li>États-Unis</li></country><region><li>Aquitaine</li><li>Auvergne-Rhône-Alpes</li><li>Massachusetts</li><li>Nouvelle-Aquitaine</li><li>Poitou-Charentes</li><li>Rhône-Alpes</li></region><settlement><li>Bordeaux</li><li>Lyon</li><li>Poitiers</li></settlement></list><tree><country name="France"><noRegion><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name></noRegion><name sortKey="Benatru, Isabelle" sort="Benatru, Isabelle" uniqKey="Benatru I" first="Isabelle" last="Bénatru">Isabelle Bénatru</name><name sortKey="Delabre, Laurene" sort="Delabre, Laurene" uniqKey="Delabre L" first="Laurène" last="Delabre">Laurène Delabre</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Elbaz, Alexis" sort="Elbaz, Alexis" uniqKey="Elbaz A" first="Alexis" last="Elbaz">Alexis Elbaz</name><name sortKey="Goldberg, Marcel" sort="Goldberg, Marcel" uniqKey="Goldberg M" first="Marcel" last="Goldberg">Marcel Goldberg</name><name sortKey="Gourlet, Veronique" sort="Gourlet, Veronique" uniqKey="Gourlet V" first="Véronique" last="Gourlet">Véronique Gourlet</name><name sortKey="Imbernon, Ellen" sort="Imbernon, Ellen" uniqKey="Imbernon E" first="Ellen" last="Imbernon">Ellen Imbernon</name><name sortKey="Mazurie, Jean Louis" sort="Mazurie, Jean Louis" uniqKey="Mazurie J" first="Jean-Louis" last="Mazurie">Jean-Louis Mazurie</name><name sortKey="Moisan, Frederic" sort="Moisan, Frederic" uniqKey="Moisan F" first="Frédéric" last="Moisan">Frédéric Moisan</name><name sortKey="Spinosi, Johan" sort="Spinosi, Johan" uniqKey="Spinosi J" first="Johan" last="Spinosi">Johan Spinosi</name><name sortKey="Spinosi, Johan" sort="Spinosi, Johan" uniqKey="Spinosi J" first="Johan" last="Spinosi">Johan Spinosi</name><name sortKey="Tzourio, Christophe" sort="Tzourio, Christophe" uniqKey="Tzourio C" first="Christophe" last="Tzourio">Christophe Tzourio</name></country><country name="États-Unis"><region name="Massachusetts"><name sortKey="Weisskopf, Marc G" sort="Weisskopf, Marc G" uniqKey="Weisskopf M" first="Marc G." last="Weisskopf">Marc G. 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